Meet Our Team
CTM team is composed by local and international scientists. The research group is highly interdisplinary due to the different background of the fellows. The researchers are recruited according to high international standard and the ability to team-play and perform...
The Center for Translational Medicine (CTM) is the Department in International Clinical Research Center (FNUSA-ICRC) dedicated to gain mechanistic insights of aging-related pathologies at the cellular and molecular levels. In particular, CTM is focused on exploring and modeling the molecular processes behind the onset and progression of cardiovascular pathologies, neurodegenerative tauopathies and early stages of diseases of aging. CTM has a special interest on investigating the possibility that the derangement or the malfunctioning of the mechanosensor apparatus in tissue-specific cells is involved in the onset or progression of such diseases.
News & Publications
CTM Principal Investigator Jan Fric participates in the research entitled "Calcineurin-mediated IL-2 production by CD11c high MHCII+ myeloid cells is crucial for intestinal immune homeostasis" by Mencarelli and colleagues published in Nature Communications.
On April 17th, The Center for Translational Medicine of FNUSA-ICRC will host the meeting "Italian Scientists in Czech Republic" within the Days of Italian Research organised by the Italian Embassy in Prague and the Ministry of Education, University and Research (MIUR). Check the program here and register at email@example.com
The article entitled "Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?" by our PhD student Shyam Sushama Jose and collaborators accepted for publication in Frontiers in Immunology.
The article entitled "Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma" by our PhD student Oriana Lo Re and collaborators accepted for publication in Hepatology.
Areas of Interest
Stem Cell Biology
Mechanical basis of pathologies
Bioengineering tools to mimic pathological conditions
Axonal transport in neurodegenerative diseases
Response of the immune system to pathologies and regeneration
Epigenetic mechanisms of liver cancer progression
Short term fasting to treat gastrointestinal cancers and aging
CTM is willing to hire a Senior Postdoctoral fellow to work in the Cardiovascular System Mechanobiology (CSM).
CTM hosts the First Investigator Meeting of the Austria-Czech Republic INTERREG project Kompetenzzentrum MechanoBiologie in Regenerativer Medizin.
CTM hits the news in Czech Republic. Check it out.
The kick-off meeting of the INTERREG project "Competence Center for Mechanobiology in Regenerative Medicine" was held at the Donau University in Krems (Austria).
The research featured in the paper entitled "YAP regulates cell mechanics by controlling focal adhesion assembly" by Giorgia Nardone, Jorge Oliver De La Cruz and collaborators accepted for publication in Nature Communications.
The paper entitled "Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein (APP) in human neurons" by Valentina Lacovich and collaborators accepted for publication in the Journal of Neuroscience.
The Center for Translational Medicine was awarded funds by the Ministry of Education Youth and Sports - MŠMT ČR for the project entitled "Unveiling the molecular determinants of aging to design new therapeutics (MAGNET). The project is meant to attract Dr. Manlio Vinciguerra to start his independent research group within CTM center and will fund CTM research until the end of 2020.
Congratulations to CTM students Shyam Sushama Jose, Federico Tidu and Oriana Lo Re who managed to join the PhD school of Masaryk University in Medical Biology. Good luck to the 3 of them.
The Minister of Finance and Deputy Prime Minister of Czech Republic Andrej Babis visited CTM laboratories in ICRC on monday 2016/06/20. The Minister appreciated the quality of the research and the outstanding technologies of the center. He was especially amazed by the international environment of the research team.
Prime Minister of Czech Republic Bohuslav Sobotka visited CTM laboratories in ICRC on saturday 2016/06/04. The Prime Minister was accompanied by deputy minister of health Teska Arnostova, USA Ambassador in Czech Republic Andrew Schapiro, the Governor of South Moravia Region Michal Hašek, and the Head of the Healthcare Committee of the Senate, Director of Masaryk Oncology Institute in Brno Jan Zaloudik.
Congratulations to Dr. Valentina Lacovich and Dr. Maria Carna for being awarded two grants from the Technology Agency of the Czech Republic (TAČR) for the proposals " Standarized axonal transport assay" (VL) and "Novel Antibody-Based Strategies to Investigate Alzheimerˈs Disease" (MC).
Congratulations to Dr. Manlio Vinciguerra, new PI of the Center for Translational Medicine (CTM), for being awarded the South Moravian Programme for Distinguished Researchers (SO.MO.PRO.). The programme is co-financed by Horizon 2020, Marie Skłodowska-Curie Actions and the South Moravian Region. Dr. Vinciguerra will start a new research group in CTM on April 1st on the Epigenetics in Metabolism and Aging. The successful project is entitled "Diets to treat gastrointestinal cancers: epigenetic mechanisms".
CTM researchers started on 01/03/2016 the project NANOSUPREMI under the auspices of H2020-MSCA-RISE-2015 program in collaboration with the University of Melbourne (Australia), Italian Institute of Technology (IIT) and the University of California Santa Barbara (USA). The project will allow for tracking nanometer-scale bioprocesses such as nanomedicines cellular uptake and trafficking, single-molecule dynamic processes of DNA-protein and protein-membrane interactions.
Integrated Center for Cell Therapy and Regenerative Medicine (ICCT) to change its name into Center for Translational Medicine (CTM).
Congratulations to Dr. Jana Amrichova, who got awarded funds from the Granting Agency of Czech Republic (GACR) for the project "Microenvironment of malignant melanoma as a factor of tumor aggressiveness" in collaboration with Charles Univeristy of Prague and the Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov.
ICCT student joins PhD course at MU, Brno.
Congratulations to Mrs Fabiana Martino who started the PhD course in Medical Biology at the Faculty of Medicine of Masaryk University of Brno.
ICCT PIs to take part in the first ICRC retreat at the University of Trieste, Italy. The retreat will be held at the Aula Rita Levi Montalcini of the Univeristy of Trieste and will include a common session with the representatives of the University.
ICCT makes the news as the 2015 open day is organized by FNUSA-ICRC.
For the first time in its history the International Clinical Research Center at the St Anne´s University Hospital in Brno (FNUSA-ICRC) has opened the doors to the interested public. Great interest in ICCT laboratories brought dozens of curious guests to visit the premises.
ICCT representatives take part in the workshop on Microfuidics and Lab-on-a-chip technologies organized by CEITEC (Central European Institute of Technology).
Integrated Centre of Cellular Therapy and Regenerative medicine cordially invites you for a lecture of prof. Gabriele Grassi from the University of Trieste. Lecture called "Molecular investigations on the anticancer activity of the demethylating agentazacytidine in hepatocellular carcinoma" will be held on September 1, 2015 from 1 p.m. at FNUSA - ICRC, building B1, 6th floor.
Researchers from ICCT participate to the International Society for Stem Cell Research (ISSCR) meeting in Stockholm, with posters entitled: "YAP mechanosensor as a crucial determinant in the differentiation of adipose tissue-derived mesenchymal stem cells", by Dr. Giorgia Nardone et al., "Rat model of sheath guided stent implantation for cell therapy" by Dr. Jana Hlozkova et al. and "The effect of reprogramming method, source cell type and long-term cell culture on genomic stability of human induced pluripotent stem cells" by Dr. Pavel Simara et al.
The vascularization of tissue engineered products represents a key issue in regenerative medicine to be addressed before the translation of these protocols to the bedside can be foreseen.
Here we propose a multistep procedure to prepare vascularized three-dimensional cardiac bio-substitutes by dynamic cultures and highly porous biocompatible gelatin scaffolds.
The strategy adopted exploits the peculiar differentiation potential of two distinct subsets of adult stem cells to obtain human vascularized 3D cardiac tissues.
Stem cell responsiveness to extracellular matrix (ECM) composition and mechanical cues has been the subject of a number of investigations so far, yet the molecular mechanisms underlying stem cell mechanobiology still need full clarification. Here we demonstrate that the paralog proteins YAP and TAZ exert a crucial role in adult cardiac progenitor cell mechano-sensing and fate decision.
Laboratory tour held in Integrated Center for Cell Therapy and Regenerative Medicine (ICCT). ICRC fellows have visited ICCT premises for the first Open Lab day to get acquainted with the state of the art in regenerative medicine and be informed about the new research projects.
Integrated Center for Cell Therapy and Regenerative Medicine (ICCT) organized the first workshop: "Microfluidics and nanotechnologies for cell biology and tissue engineering applications". The workshop was hosted by FNUSA-ICRC on March 11-12 and saw the participation of researchers from Czech Republic, Italy and Saudi Arabia.